涓浗縐戝ぇ鐢熷懡縐戝涓庡尰瀛﹂儴鐢板織鍒氳棰樼粍鍙戠幇錛岃倽鑴忎腑瀛樺湪涓€緹よ兘璐熻皟T緇嗚優鎶楃梾姣掑厤鐤簲絳旂殑鐗規畩NK緇嗚優錛屽茍鎻ず浜嗗叾鍔熻兘鍙戞尌鐨勬満鍒躲€傜浉鍏蟲垚鏋滄棩鍓嶅彂琛ㄤ簬銆婄粏鑳炪€嬪嚭鐗堥泦鍥㈡棗涓嬨€婂厤鐤€嬫潅蹇椼€?/span>
鑲濊剰鍏鋒湁鐙壒鐨勫厤鐤€愬彈灞炴€э紝鏄澶氱梾姣掑湪浣撳唴榪涜澶嶅埗鐨勪富瑕佸満鎵€銆傝倽鑴廡緇嗚優寰€寰€涓嶈兘浜х敓鏈夋晥鐨勫厤鐤簲絳斿幓娓呴櫎鐥呮瘨錛岄€犳垚鐥呮瘨鎸佺畫鎬ф劅鏌撱€傜劧鑰岋紝鑲濊剰T緇嗚優鎶楃梾姣掕兘鍔涗綆涓嬬殑璋冩帶鏈哄埗騫朵笉鍗佸垎娓呮銆?/span>
鑷劧鏉€浼わ紙NK錛夌粏鑳炴槸鏈轟綋閲嶈鐨勫厤鐤粏鑳烇紝琚涓哄驚鐜穻宸寸粏鑳炪€備互寰€瀵瑰驚鐜殑甯歌NK緇嗚優錛坈NK錛夌爺絀舵彁紺猴紝鍏跺湪鎶墊姉鐥呮瘨鎰熸煋鐨勮繃紼嬩腑鍙戞尌閲嶈浣滅敤銆?/span>
鐢板織鍒氱爺絀剁粍2013騫村湪鍥介檯涓婇嬈℃姤閬撲簡涓€緹ょ嫭鐗圭殑瀹氬眳浜庤倽鑴忕殑NK緇嗚優緹や綋錛圠rNK錛夈€傚畠浠笉鍙備笌琛€娑插驚鐜紝騫朵笖涓巆NK緇嗚優鍦ㄥ熀鍥犲拰铔嬬櫧姘村鉤涓婂憟鐜版樉钁楀樊寮傘€?/span>
鍦ㄦ渶鏂扮爺絀朵腑錛岀爺絀朵漢鍛樺埄鐢↙rNK緇嗚優緙洪櫡灝忛紶榪涜瀹為獙錛屽彂鐜板叾琚梾姣掓劅鏌撳悗錛岃倽鑴忎腑T緇嗚優鍔熻兘澧炲己錛岃倽鑴忔崯浼ゅ姞閲嶏紝鐥呮瘨鍑忓皯銆傚姝ｅ父灝忛紶鎴朙rNK緇嗚優緙洪櫡灝忛紶澶栨簮杞緭LrNK緇嗚優錛屽垯浼氭姂鍒惰倽鑴忎腑T緇嗚優鐨勬姉鐥呮瘨鍙嶅簲錛岃€宑NK緇嗚優淇冭繘T緇嗚優鎶楃梾姣掑簲絳斻€傝繖琛ㄦ槑錛孡rNK緇嗚優鍜宑NK緇嗚優鍦ㄦ姉鐥呮瘨鎰熸煋涓搗鍒扮浉鍙嶄綔鐢ㄣ€侺rNK緇嗚優鎶戝埗鑲濊剰涓璗緇嗚優鐨勬姉鐥呮瘨鍙嶅簲錛屼粠鑰屽鑷寸梾姣掓竻闄よ緝鎱紝cNK緇嗚優鍒欏姞蹇梾姣掓竻闄ゃ€備綋鍐呭瀹為獙榪涗竴姝ュ彂鐜幫紝LrNK緇嗚優渚濊禆浜庡叾琛ㄩ潰鐨勪竴縐峆D-L1铔嬬櫧錛屽鑲濊剰涓璗緇嗚優鐨勫姛鑳戒駭鐢熸姂鍒躲€?/span>
璇ユ垚鏋滅郴緇熼槓榪頒簡LrNK涓巆NK緇嗚優鍦ㄨ皟鎺緇嗚優搴旂瓟鏂歸潰瀹屽叏鐩稿弽鐨勫姛鑳斤紝鎻愮ずLrNK緇嗚優鍦ㄨ倽鑴忓厤鐤€愬彈寰幆澧冪殑緇存寔涓壆婕旂潃閲嶈浣滅敤錛屼負鐞嗚ВNK緇嗚優浜氱兢緇勬垚涓庡尯鍩熷厤鐤壒鎬у閫犱箣闂寸殑鍐呭湪鑱旂郴鎻愪緵浜嗘柊渚濇嵁銆?/span>
鎽樿嚜縐戝緗戯細http://paper.sciencenet.cn/htmlpaper/2019/3/20193813181277949392.shtm?id=49392
